1.3 蛋白质合成场所: 核糖体(Ribosomes)

核糖体组成成份 (Components of ribosome)


★rRNA serves as scaffold molecule for three dimensional structure of ribosome.(rRNA 构成核糖体的骨架)
rRNA

★rRNA在核糖体装配和蛋白质翻译中起重要作用.
· 1. Maintaining structure of ribosome. Delete rRNA and ribosome will collapse.(维持核糖体结构)
· 2. Involved in binding to mRNA.(结合mRNA)
· 3. Key component in protein synthesis.(参与蛋白质合成)
Illustration of protein synthesis in prokaryote
原核生物蛋白质生物合成

★P位:肽酰位(Peptidyl site)
D/donor site
★A位:氨基酰位
(Aminoacyl site)
Acceptor site
★E位:排出位
(Exit site)
核糖体在蛋白合成的中的主要功能
★① Containing protein-conducting channel(通道)
★② Containing binding sites of IF, EF andRF(蛋白质合成因子结合位点)
★③ Containing three RNA binding sites, “给位”( donor site, D 位); “肽位”(peptidyl site , P 位); “受位”( acceptorsite, 氨基酰位, aminoacyl site ,A 位)
★④ Peptidyltransferase activity (转肽酶活性)
★⑤GTPaseactivity(GTP酶活性)

