研究领域

1.      微生物法污水处理

2.      环境功能材料的开发与利

3.      膜技术在污水处理中的应用

论文与著

科研项目及人才计划项目情况：
1. 分离用温度敏感聚偏氟乙烯中空纤维膜关键技术研究  国家高技术研究发展计划(863计划)
2. 原子转移自由基聚合法制备温敏性聚偏氟乙烯及其成膜过程与分离性能研究国家自然科学基金
3. 漆酶在褐腐菌接触纤维素机制中作用的研究   国家自然科学基金
4. 褐腐菌接触纤维素机制的研究    教育部留学回国人员科研启动基金
5. 温敏支架材料表面纳微米结构设计及其对细胞行为的调控国家自然科学基金
6. 纳米拓扑智能膜的构建及其对细胞行为影响的研究  天津市自然科学基金
7. 糖化温敏凝胶及其与细胞相互作用研究  国家自然科学基金
8. 细胞活化温敏凝胶膜的研究  教育部高校博士点基金
9. 肝组织工程用温敏凝胶及其生物相容性研究  天津市高等学校科技发展基金
代表性研究成果：
1. Xiao-Ling He*, Li-Li Ge, Ze-Li Liu, Wen-Jia Lu, Jia-Quan Li, Yue-Mei Zhao, Xiang-Xu Li, Ning Yang, Li Chen*, and Dong-Sheng Wei. Glycyrrhetinic acid-based thermoresponsive hydrogel as a synthetic extracellular matrix for hepatocyte culture and recovery. Industrial & Engineering Chemistry Research, 2014,53:10618— 10628.
2. Xiao-Ling He, Ping-Ping Nie, Bi-Zhou Chen, Xiang-Xu Li, Li Chen*. A novel method to fabricate thermoresponsive microstructures with improved cell attachment /detachment properties. Journal of Biomedical Materials Research Part A, 2012, 100 A (8):1946—1953.
3. Xiao-Ling He, Ping-Ping Nie, Yan-Kai Sun, Ying Wang, You-Yu Dong, Li Chen*.   Immobilization of galactose ligands on thermoresponsive culture surface and its influence on cell adhesion /detachment. Journal of Colloid and Interface Science, 2010,350:471—479.
4. Xiao-ling He, Shen Yu, You-Yu Dong, Fan-Yong Yan, Li Chen*. Preparation and properties of a novel thermo-responsive poly(N-isopropylacrylamide) hydrogel containing glycyrrhetinic acid. Journal of Materials Science, 2009,44(15):4078— 4086.
5. Xiao-ling He, Yi-Ping Zhao, You-Yu Dong, Li Chen*, Jing Dong. Photografting of poly(N-isopropylacrylamide) and galactose onto tissue culture polystyrene. The 238th ACS National Meeting, 194, Washington,DC, 2009.07.16—20.
6. Yue-mei Zhao, Xiao-ling He *, Jia-quan Li, Xiang-xu Li, Li Chen* and Dong-sheng Wei. Preparation and properties of thermosensitive poly(N-isopropylacrylamide-co-glycyrrhetinic acid) microgels for controlled growth factor release. Applied Mechanics and Materials, 2014,457-458:148—151.
7. Xia Feng, Yanfen Guo, Xi Chen, Yiping Zhao, Jianxin Li, Xiao-ling He, Li Chen *. Membrane formation process and mechanism of PVDF-g-PNIPAAm thermo-sensitive membrane. Desalination, 2012,290:89—98.
8. Xia Feng, Yanfen Guo, Yiping Zhao, Jianxin Li, Xi Chen, Xiao-ling He, Li Chen *.Influence of Coagulant Temperature on the Membrane Formation Process and Properties of PVDF -g- PNIPAAm Temperature-sensitive Membranes. Chemical Journal of Chinese Universities - Chinese. 2011,32(6):1424—1430.
9. Ping-Ping Nie, Xiao-Ling He, Li Chen*. Temperature-sensitive chitosan membranes as a substrate for cell adhesion and cell sheet detachment. Polymers for advanced  technologies, 2010,23(3):447—453.
10. Ping-Ping Nie, Xiao-ling He, Li Chen*. A thermoresponsive topography substrate for cell adhesion, growth and thermally induced detachment. 2010 international forum on biomedical textile materials. 2010,215—219, Shanghai.
11. You-Yu Dong, Xiao-Ling He, Li Chen*, Fan-Yong Yan, Hao-Jie Li. The effect of AAc-GA content on swelling behaviors of temperature-sensitive PNIPAAm-based hydrogels. Frontiers Materials Science in China, 2010,4(1):84—89.
12. Si-xin Bi, Ning Yang, Miao-kun Yang, Xiao-ling He, Li Chen*, Zheng-yan Zhu,Ying-tang Gao, Zhi Du. Fabrication of polystyrene microscale porous substrate and its effects on HL-7702 cells behaviors. Journal of Biomedical Materials Research Part A, 2014,102A :1518—1526.
13. Miao-kun Yang, Ning Yang, Si-xin Bi, Xiao-ling He, Li Chen*, Zheng-yan Zhu, Ying-tang Gao and Zhi Du. Micropatterned designs of thermoresponsive surfaces for modulating cell behaviors. Polymers for advanced  technologies, 2013, 24:1102 — 1109.